Helicobacter pylori (HP) ibhakitiriya inogara mudumbu uye inonamatira kune gastric mucosa uye intercellular spaces, zvichikonzera kuzvimba.Utachiona hweHP ndehumwe hwehutachiona hwehutachiona, hunobata mabhiriyoni evanhu pasi rose.Ndivo vanonyanya kukonzera maronda uye gastritis (kuzvimba kwedumbu remukati).

Utachiona hwepamusoro muvana uye kuunganidzwa kwemhuri ndiwo akakosha maitiro ehutachiona hweHP, uye kutapurirana kwemhuri kunogona kunge iri nzira huru HP hutachiona ndiyo hombe inokonzeresa mune isingaperi inoshanda gastritis, peptic ulcer, gastric mucosa-associated lymphoid tishu (MALT) lymphoma, uye gomarara remudumbu.Muna 1994, World Health Organization/International Agency for Research on Cancer (WHO/IARC) yakasarudza Helicobacter pylori sekirasi I carcinogen.

Gastric mucosa - chombo chemuviri chedumbu

Mumamiriro ezvinhu akajairwa, madziro emudumbu ane akatevedzana akakwana ekuzvidzivirira maitiro (iyo secretion yegastric acid uye protease, kuchengetedzwa kweasinga nyungudika uye soluble mucus layers, kugara uchirovedza muviri, nezvimwewo), izvo zvinogona kuramba kupinda kwezviuru zvema microorganisms. dzinopinda nomuromo.

HP ine yakazvimirira flagella uye yakasarudzika helical dhizaini, iyo isingangoite basa rekusimbisa panguva yehutachiona hwekoloni, asi zvakare inogona kuve yakatenderera uye kugadzira inozvidzivirira morphology munzvimbo dzakaoma.Panguva imwecheteyo, Helicobacter pylori inogona kubudisa zvakasiyana-siyana zvehupfu, izvo zvinotarisa kuti Helicobacter pylori inogona kupfuura nepakati pegastric juice layer kuburikidza nesimba rayo uye inodzivisa gastric acid nezvimwe zvinhu zvisingafadzi, ichiva iyo chete microorganism inogona kurarama mudumbu remunhu. .

Pathogenesis yeHelicobacter pylori

1. Dynamic

Zvidzidzo zvakaratidza kuti Helicobacter pylori ine simba rakasimba rekufamba munzvimbo ine viscous, uye flagella inofanirwa kuti mabhakitiriya ashambire kune inodzivirira mucus layer pamusoro pegastric mucosa.

2. Endotoxin-yakabatana neprotein A (CagA) uye vacuolar toxin (VacA)

Cytotoxin-yakabatana gene A (CagA) protein yakavanzwa neHP inogona kukonzeresa kuzvimba kwenzvimbo.CagA-positive Helicobacter pylori chirwere chinogonawo kuwedzera zvakanyanya njodzi yeatrophic gastritis, intestinal metaplasia uye kenza yemudumbu.

Vacuolating cytotoxin A (VacA) ndechimwe chinonyanya kukosha pathogenic factor yeHelicobacter pylori, inogona kupinda mitochondria kugadzirisa basa re organelles.

3. Flagellin

Mapuroteni maviri eflagellin, FlaA neFlaB, anoumba zvikamu zvikuru zveflagellar filaments.Shanduko mu flagellin glycosylation inokanganisa strain motility.Apo chiyero cheFlaA protein glycosylation chakawedzerwa, zvose kukwanisa kutama uye mutoro wekoloni wekutambudzika kwakawedzera.

4. Urease

Urease inogadzira NH3 uye CO2 nehydrolyzing urea, iyo inoderedza gastric acid uye inosimudza pH yemaseru akatenderedza.Mukuwedzera, urease inobatanidzwa mumhinduro dzekuvhiringidza uye inokurudzira kunamatira kuburikidza nekubatana neCD74 receptors pane gastric epithelial cells.

5. Kupisa kunotyisa kweprotein HSP60/GroEL

Helicobacter pylori inobata mutsara wezvakachengetwa zvakanyanya kupisa kupisa mapuroteni, ayo anobatana-kutaura kweHsp60 ne urease muE. coli inowedzera zvakanyanya urease basa, zvichiita kuti pathogen igadzirise uye irarame munharaunda ine hutsinye ecological niche yemudumbu wemunhu.

6. Mapuroteni ane haka 2 homolog FliD

FliD ipuroteni yakaumbwa inochengetedza muromo weflagella uye inogona kudzokorodza kuisa flagellin kuti ikure mafilaments.FliD inoshandiswawo seadhesion molecule, ichiziva glycosaminoglycan mamorekuru emasero anotambira.Mune vanhu vane hutachiona, maanti-flid masoja ekudzivirira chirwere zviratidzo zvehutachiona uye anogona kushandiswa serological kuongororwa.

Nzira dzekuedza:

1. Muedzo westool: The stool antigen test is a non-invasive test yeH. pylori.Iko kuvhiya kwakachengeteka, kwakapusa uye nekukurumidza, uye hakudi nemuromo kutonga kwechero reagents.

2. Kuonekwa kweSerum antibody: Kana chirwere cheHelicobacter pylori chikaitika mumuviri, muviri wemunhu uchava ne-anti-Helicobacter pylori antibodies muropa nekuda kwekudzivirira.Nekukwevera ropa kutarisa kuwanda kwemasoja ekudzivirira chirwere anonzi Helicobacter pylori, anogona kuratidza kana pane Helicobacter pylori mumuviri.utachiona hwehutachiona.

3. Kuedzwa kwekufema: Iyi inzira yekuongorora yakakurumbira parizvino.Oral urea ine 13C kana 14C, uye kufema kuedza kukanganiswa kwekabhoni dioxide ine 13C kana 14C mushure menguva yenguva, nokuti kana pane Helicobacter pylori, urea ichaonekwa neayo chaiyo urea.Ma enzymes anoputsika kuita ammonia uye kabhoni dhaikisaidhi, iyo inoburitswa kubva mumapapu kuburikidza neropa.

4. Endoscopy: inobvumira kunyatsotarisa kutarisa kwegastric mucosal zvinhu zvakadai sekutsvuka, kuzvimba, kuchinja kwenodular, nezvimwewo;endoscopy haina kukodzera kuvarwere vane zvinetso zvakakomba kana zvinopesana uye mamwe mari (anesthesia, forceps) .

Bioantibody inoenderana zvigadzirwa zveH.pylorizvinokurudzirwa:

H. Pylori Antigen Rapid Test Kit (Lateral Chromatography)

H. Pylori Antibody Rapid Test Kit (Lateral Chromatography)